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Dr. Mitchell Rosen Physician at UCSF

Professional Overview AboutBlog
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Reproductive Endocrinology & Fertility Expert

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Director of the UCSF Fertility Preservation Center

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Assistant Professor of Medicine

Dr. Mitchell Rosen is a reproductive endocrinology and fertility expert at the UCSF Center for Reproductive Health. He also serves as the Director of the UCSF Fertility Preservation Center, which helps patients with cancer preserve their ability to have children, despite aggressive cancer treatment. In addition to caring for patients, Rosen serves as an Assistant Professor of Medicine at UCSF, where he teaches medical students, residents and fellows.

He truly enjoys his work within the field of reproductive endocrinology and fertility. Fertility is something that most people take for granted, and when it is taken away from someone it can become extremely difficult to cope with. For Mitchell Rosen, there is nothing more rewarding than helping people through such an emotional and stressful situation. He is motivated each day to keep pushing for breakthroughs in the field so that more couples can realize their dream of raising a child.

Education

Dr. Mitchell Rosen earned a medical degree at Saint Louis University and completed residency training in obstetrics and gynecology at the University of Texas Medical Branch in Galveston, Texas. During his medical and residency training, he was named the best resident twice and received the Ortho-McNeil Best Resident Teacher Award in 2002.

Mitchell Rosen completed fellowship training in reproductive endocrinology and infertility at UCSF.  During his fellowship, Rosen explored a basic research interest in a candidate gene (DAZ-L) involved in gametogenesis. He determined that this gene may be involved in the age at ovarian failure and spermatogenesis. Dr. Rosen was later trained in the UCSF embryology laboratory to qualify as a high complexity lab director (HCLD).

Research

Dr. Mitchell Rosen is actively involved in studies to better understand the impact of exogenous stimulation on in vivo and subsequent in vitro oocyte development and maturation. Of particular interest is understanding ways to optimize controlled ovarian hyperstimulation to improve pregnancy outcomes during assisted reproduction.

Mitchell Rosen has recently received funding to develop a randomized trial evaluating concomitant FSH with hCG for ovulation trigger. During a spontaneous ovulatory surge, there is a rise in both FSH and LH. While hCG has been substituted for the LH surge, no studies have addressed the role of FSH on the developing oocyte during the final steps of nuclear and cytoplasmic maturation. This prospective study will compare ovarian stimulation and follicular development, along with oocyte maturation, developmental competence, and quality between those participants receiving hCG alone or combined FSH/hCG. In addition, the intrafollicular hormonal milieu, embryo quality, and pregnancy rates will be compared between the two treatment groups.

Involved in several other studies, Mitchell Rosen of UCSF focus on optimizing embryo selection, leading to single embryo transfer, and thereby decreasing health risks to women and their children. We have established a protocol utilizing proton magnetic spectroscopy and HPLC proteomics to compare embryos with and without known implantation.

Additionally, Dr. Mitchell Rosen is a member of a research team addressing the role of methyl-tetrahydrafolate reductase in ovarian stimulation and IVF outcomes, and the effect CMV in semen has on fertilization and embryo quality. Ultimately, his goal is to promote a team effort between clinicians, basic scientists, and embryologists in order to better study folliculogenesis and apply this knowledge to understanding the process of ovarian aging and the impact of exogenous medications on follicle development.

Get in touch with Dr. Mitchell Rosen